{"id":57679,"date":"2024-02-08T14:16:47","date_gmt":"2024-02-08T13:16:47","guid":{"rendered":"https:\/\/www.nordnet.dk\/blog\/?p=57679"},"modified":"2025-05-12T08:39:24","modified_gmt":"2025-05-12T06:39:24","slug":"nyt-haab-for-kraeftpatienter","status":"publish","type":"post","link":"https:\/\/www.nordnet.dk\/blog\/nyt-haab-for-kraeftpatienter\/","title":{"rendered":"Nyt h\u00e5b for kr\u00e6ftpatienter"},"content":{"rendered":"\n<p><strong>Avanceret blodpr\u00f8vetest kan nu i h\u00f8jere grad afsl\u00f8re, om en kr\u00e6ftbehandling har fjernet kr\u00e6ften helt, eller om der er risiko for tilbagefald. Dette kan v\u00e6re et gennembrud for behandling af kr\u00e6ftpatienter. Metoden er hurtig, billig og mere pr\u00e6cis end traditionelle metoder.<\/strong><\/p>\n\n\n\n<p>Et afg\u00f8rende sp\u00f8rgsm\u00e5l for patienter, der er blevet behandlet for kr\u00e6ft er, om sygdommen er helt v\u00e6k, eller om den stadig ligger latent i kroppen og kan vende tilbage. I l\u00e6gevidenskaben omtales en forsat tilstedev\u00e6relse af kr\u00e6ftceller i kroppen efter afsluttet behandling som \u201dminimal resterende sygdom\u201d (MRD forkortet p\u00e5 engelsk).<\/p>\n\n\n\n<p>Traditionelt har det udstyr, der bruges til at generere billeder\/r\u00f8ntgen af kroppen, s\u00e5som CT, PET og MRI v\u00e6ret anvendt til at vurdere MRD ved at lede efter resterende kr\u00e6ftceller eller nye l\u00e6sioner (dvs. skader eller ikke normale \u00e6ndringer i v\u00e6v eller organer). Traditionelle metoder har imidlertid en begr\u00e6nset pr\u00e6cision og kan ofte ikke detektere resterende kr\u00e6ftceller, f\u00f8r de n\u00e5r et relativt avanceret stadie.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cEt afg\u00f8rende sp\u00f8rgsm\u00e5l for patienter, der er blevet behandlet for kr\u00e6ft, er, om sygdommen er helt v\u00e6k.\u201d<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"en-ny-metode-er-noglen\">En ny metode er n\u00f8glen<\/h2>\n\n\n\n<p>I l\u00f8bet af det seneste \u00e5rti har fremkomsten af v\u00e6skebiopsier og avanceret genteknologi gjort det muligt at udvikle meget f\u00f8lsomme, blodbaserede tests til MRD-detektion og -overv\u00e5gning. Disse nye blodbaserede metoder analyserer et s\u00e5kaldt cirkulerende tumor-DNA (ctDNA), der frigives i blodet af kr\u00e6ftceller og kan identificere selv minimale spor af eventuel resterende sygdom eller tilbagefald.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"fordele-ved-blodbaseret-mrd-testning\">Fordele ved blodbaseret MRD-testning<\/h2>\n\n\n\n<p>Sammenlignet med traditionelle, billedbaserede metoder til diagnosticering af kr\u00e6ft har blodbaserede v\u00e6skebiopsier som n\u00e6vnt flere fordele:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>St\u00f8rre f\u00f8lsomhed: <\/em>ctDNA-baserede MRD-tests kan detektere tumor-DNA op til 100 gange mere f\u00f8lsomt end udstyr som f.eks. PET\/CT-skanninger, hvilket muligg\u00f8r detektering af bare f\u00e5 tilbagev\u00e6rende kr\u00e6ftceller.<\/li>\n\n\n\n<li><em>Seriel overv\u00e5gning: <\/em>V\u00e6skebiopsier muligg\u00f8r hyppig og regelm\u00e6ssig pr\u00f8vetagning ved at overv\u00e5ge patienten over tid. Hyppig sporing af kr\u00e6ftceller muligg\u00f8r tidlig opdagelse af tilbagefald og s\u00e5ledes hurtigere iv\u00e6rks\u00e6ttelse af behandling.<\/li>\n\n\n\n<li><em>Lavere omkostninger: <\/em>Selvom v\u00e6skebiopsi kr\u00e6ver en indledende <a href=\"https:\/\/www.nordnet.dk\/academy\/forste-investering\">investering<\/a> i sekventeringsudstyr, er ctDNA-analyse relativ billig ift. de h\u00f8je omkostninger ved gentagne r\u00f8ntgenunders\u00f8gelser. Dette underst\u00f8tter ligeledes rutinem\u00e6ssig overv\u00e5gning, hvor det er n\u00f8dvendigt.<\/li>\n\n\n\n<li><em>Mere sk\u00e5nsom: <\/em>Blodpr\u00f8vetagning p\u00e5virker kroppen minimalt ift. gentagne uds\u00e6ttelser for str\u00e5ling og kontrastmidler. Hertil er en blodpr\u00f8ve mindre tidskr\u00e6vende.<\/li>\n\n\n\n<li><em>Molekyl\u00e6r karakterisering: <\/em>Ud over at kvantificere MRDkanctDNA-analyse giveoplysninger om specifikke mutationer forbundet med behandlingsresistens og kan s\u00e5ledes hj\u00e6lpe med at tr\u00e6ffe den rigtige afg\u00f8relse ift. behandling.<\/li>\n<\/ul>\n\n\n\n<p>Sammenfattet har den blodbaserede MRD-testning betydelige fordele ift. r\u00f8ntgenunders\u00f8gelser, at metoden med stor sandsynlighed vil f\u00e5 \u00f8get anvendelse. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"selskaber-der-udvikler-de-nye-tests\">Selskaber, der udvikler de nye tests<\/h2>\n\n\n\n<p>Flere medicinalselskaber har i dag udviklet blodbaserede MRD-test. De v\u00e6sentligste er n\u00e6vnt nedenfor.<\/p>\n\n\n\n<p>Medicinalselskabet Natera har udviklet den s\u00e5kaldte Signatera-test, der i \u00f8jeblikket en af de mest avancerede ctDNA-tests. Den er blevet testet i flere kr\u00e6ftformer som f.eks. kr\u00e6ft i bl\u00e6re, tyktarm, bryst og lunger. I tilf\u00e6lde af invasiv bl\u00e6rekr\u00e6ft demonstrerede Signatera-testen sig i gennemsnit 96 dage hurtigere til at vise tilbagefald sammenlignet med r\u00f8ntgenunders\u00f8gelser. Ved tyktarmskr\u00e6ft viser Signateratesten tilsvarende lovende resultater. Med en positiv ctDNA-test fire uger efter operation indikerer testen en 97% sandsynlighed for tilbagefald uden behandling. Derudover er Signatera-testen her i stand til at opdage tilbagefald knapt 9 m\u00e5neder tidligere end r\u00f8ntgenunders\u00f8gelser. Yderligere unders\u00f8gelser inden for andre kr\u00e6ftformer er i gang, hvilket positionerer Signatera-testen som en banebrydende v\u00e6skebiopsitest.<\/p>\n\n\n\n<p>Derudover har Guardant Health udviklet en test, der kan diagnosticere resterende kr\u00e6ftsygdom og tilbagefald af tyktarmskr\u00e6ft i stadie II og stadie III, og Adaptive Biotechnologies har lanceret en MRD-test kaldet CloneSEQ, der kan spore flere typer af blodcancer.<\/p>\n\n\n\n<p>Flere andre virksomheder, herunder Exact Sciences, Invitae og NeoGenomics udvikler ogs\u00e5 MRD-tests, men det vil tage adskillige \u00e5r, f\u00f8r de kan opn\u00e5 myndighedernes godkendelse.<\/p>\n\n\n\n<p>Disse nye tests er bl.a. muliggjort af fremskridt gjort af Illumina, som er f\u00f8rende inden for gensekventeringsteknologi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"stort-fremtidigt-potentiale\">Stort fremtidigt potentiale<\/h2>\n\n\n\n<p>Blodbaseret MRD-testning har vist sig gavnlig i al kr\u00e6ftbehandling og har potentiale til at revolutionere den kliniske praksis:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>Overv\u00e5gning af respons p\u00e5 terapi: <\/em>De hurtigere testsignaler muligg\u00f8r hurtigere tilpasning af igangv\u00e6rende behandling. MRD-test efter en kr\u00e6ftoperation- eller behandling kan fort\u00e6lle om patienter kan afslutte behandlingen, eller om der er brug for yderligere behandling.<\/li>\n\n\n\n<li><em>Udvikling af nye l\u00e6gemidler: <\/em>Ved at implementere MRD-test i kliniskefors\u00f8g vil l\u00e6ger mere n\u00f8jagtigt kunne overv\u00e5ge forekomsten af resterende kr\u00e6ftceller. Dette kan forbedre viden om den optimale behandlingsform, dosis og behandlingsinterval, hvilket forventes at \u00f8ge sandsynligheden for helbredelse.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"764\" height=\"504\" src=\"https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5.png\" alt=\"\" class=\"wp-image-57680\" style=\"width:1031px;height:auto\" srcset=\"https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5.png 764w, https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5-620x409.png 620w, https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5-150x99.png 150w, https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5-500x330.png 500w, https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5-370x244.png 370w, https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5-270x178.png 270w, https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5-570x376.png 570w, https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/image-5-740x488.png 740w\" sizes=\"auto, (max-width: 764px) 100vw, 764px\" \/><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cI takt med at testf\u00f8lsomheden forbedres, og produkterne videreudvikles, har MRD-testning potentiale til at blive en standardprocedure i forbindelse med kr\u00e6ftbehandling.\u201d<\/p>\n<\/blockquote>\n\n\n\n<p>Som det kan ses af figur 1 ovenfor, er de videnskabelige artikler om ctDNA-teknologien i hastig fremmarch. Vi forventer, at denne nye teknologi vil forts\u00e6tte med at finde nye anvendelsesomr\u00e5der i takt med, at vi f\u00e5r mere viden og dokumentation for dens fordele og effektivitet baseret p\u00e5 videnskabelige forskningsresultater.<\/p>\n\n\n\n<p>I fremtiden vil bredere klinisk anvendelse af ctDNA-baseret MRD-testning blive muliggjort af den fortsatte teknologisk innovation, yderligere kliniske unders\u00f8gelser og forventeligt faldende omkostninger. I takt med at testf\u00f8lsomheden forbedres, og produkterne videreudvikles, har MRD-testning potentiale til at blive en standardprocedure i forbindelse med kr\u00e6ftbehandling. L\u00f8bende testning af patienter overv\u00e5gning vil give onkologer mulighed for overv\u00e5ge sygdomsforl\u00f8bet i \u201drealtid\u201d og bane vejen for en mere individuel tilpasset medicinering og behandling. MRD-testning rummer et opl\u00f8ftende potentiale for forbedret behandling af kr\u00e6ftpatienter gennem tidligere og bedre informerede behandlingsbeslutninger.<\/p>\n\n\n\n<p>Investeringsforeningen C WorldWides afdelinger har pt. ingen eksponering mod de omtalte selskaber.<\/p>\n\n\n\n<p><em>Materialet er produceret af C WorldWideog skal anses som markedsf\u00f8ringsmateriale. Form\u00e5let med materialet er at give generel information om afdelingerne og skal ikke betragtes som en investeringsanbefaling. Nordnet tager forbehold for n\u00f8jagtigheden af de angivne informationer, hvad enten de er leveret af C WorldWide selv eller hentet fra offentligt tilg\u00e6ngelige kilder.<\/em><\/p>\n\n\n\n<p><em>Nordnet er ikke ansvarlig for dispositioner eller undladelser foretaget p\u00e5 baggrund af informationerne. Nordnet anbefaler sagkyndig og professionel vejledning ved investeringsbeslutninger. Nordnet modtager provision fra C WorldWide. Se alle satser <\/em><a href=\"https:\/\/www.nordnet.dk\/dk\/info\/aop\"><em>her<\/em><\/a><em>.<\/em><\/p>\n\n\n\n<p><em>Historiske og tidligere afkast og\/eller kursudviklinger kan ikke anvendes som p\u00e5lidelig indikator for fremtidige afkast og\/eller kursudvikling. Tegning af andele b\u00f8r ske p\u00e5 baggrund af prospekt, vedt\u00e6gter og central investorinformation. Informationen findes p\u00e5 <\/em><a href=\"https:\/\/www.cworldwide.dk\/produkter\/stabile-aktier\/\" rel=\"nofollow noopener\"><em>cworldwide.dk<\/em><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Avanceret blodpr\u00f8vetest kan nu i h\u00f8jere grad afsl\u00f8re, om en kr\u00e6ftbehandling har fjernet kr\u00e6ften helt, eller om der er risiko for tilbagefald. Dette kan v\u00e6re et gennembrud for behandling af kr\u00e6ftpatienter. Metoden er hurtig, billig og mere pr\u00e6cis end traditionelle metoder.<\/p>\n","protected":false},"author":68593,"featured_media":57682,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ghostkit_customizer_options":"","ghostkit_custom_css":"","ghostkit_custom_js_head":"","ghostkit_custom_js_foot":"","ghostkit_typography":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[1291],"tags":[],"class_list":["post-57679","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-analyse"],"acf":[],"all_images":{"thumbnail":{"src":"https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/bio_1200x430-150x54.png","width":150,"height":54,"crop":true,"srcset":"https:\/\/blog.nordnet.dk\/wp-content\/uploads\/sites\/4\/2024\/02\/bio_1200x430-150x54.png 150w, 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